CBD folks –
Here’s a case report out of UCSF of someone with a clinical diagnosis of CBD who had a seizure. The abstract says: “To our knowledge, however, there have been no reports of seizures associated with corticobasal degeneration (CBD).” Perhaps nothing has been published in the medical literature about this but there are plenty of case reports available on the CBD-related Yahoo!Group about seizures! I note that this patient had a brain biopsy where the results were “suggestive of CBD.” Of course the only conclusive diagnosis of CBD is available in a brain autopsy (upon death). On a living patient, a pathologist or surgeon can’t get to the right areas of the brain to confirm CBD. The risks of a brain biopsy are not insignificant; my impression is that a biopsy is done (on living patients) only in extreme cases.
Robin
Neurocase. 2009 Jun 18:1-5. [Epub ahead of print]
Seizures in corticobasal degeneration: A case report.
Douglas VC, Dearmond SJ, Aminoff MJ, Miller BL, Rabinovici GD.
Neurology Clinic, University of California, San Francisco, CA, USA.
Seizures are relatively common in Alzheimer disease (AD) and other neurodegenerative disorders. To our knowledge, however, there have been no reports of seizures associated with corticobasal degeneration (CBD). We describe a patient with brain biopsy features suggestive of CBD whose course was complicated by complex partial seizures with secondary generalization. Thus, the occurrence of seizures in a patient with dementia should not exclude the diagnosis of CBD.
PubMed ID#: 19544144 (see pubmed.gov for this free abstract only)